For more than 70 years, Silverson has focused on manufacturing high-quality high-shear mixers for the global processing and manufacturing industries.

Silverson has customers in more than 150 countries, serving a variety of industries such as food, pharmaceuticals, cosmetics, lubricants and petrochemicals, and has become a global leader in the field of high shear mixing. The company has designated Silverson mixers time and time again as the "standard" equipment for its manufacturing process.

The key to this success lies in Silverson's professionalism and commitment to the needs of each customer. Whether it is to provide standard mixer series machines or equipment specially designed to meet individual customer requirements, the quality is guaranteed.

Silverson's customer base includes many of the world's largest companies, so it is always at the forefront of new technologies. By developing and applying new high-shear mixing technology to meet these needs, Silverson has a wealth of experience, knowledge and commitment in quality and service that can solve today's and future mixing needs.

Silverson is a truly international company with a network of affiliates, distributors and agents in more than 50 countries/regions, serving North America, Europe, Asia, Australasia, South America and Africa.

The latest development in high-shear laboratory mixing-the new Silverson L5M-A-is ideal for all laboratory work, R&D, quality assurance analysis and small-scale production in all industries.

Silverson's sanitary mixer series is 3A type and EHEDG certified, and its design meets FDA and cGMP requirements.

Silverson's Hygienic Series High Shear Bottom Inlet Mixer is designed to be installed on the bottom or side of a mixing vessel. These high-shear mixers are usually used in combination with low-speed anchor agitators or scraper devices for high-viscosity products.

Dispersing the powder into the liquid again and again and producing a consistent homogeneous product is the most difficult aspect of all mixing applications. To meet this need, Silverson developed Flashblend, a high-shear system for quickly mixing various powders, including problematic gums and thickeners.

Silverson Flashmix uses a revolutionary method to mix powder/liquid. Unlike many powder/liquid mixers that use vacuum inhalation of powder, Flashmix literally forces the powder into the liquid stream. This not only allows it to disperse and hydrate large amounts of powder, which means it can be used in higher temperature and higher viscosity mixtures-providing the advantages of high shear mixing for a wide range of applications that were not possible before.

The Silverson mixer homogenizer is fast and efficient and can produce small droplets or particle sizes, usually in the range of 2-5 microns. This degree of homogenization is suitable for most products, such as sauces and flavor lotions, creams and lotions.

Silverson's high viscosity (HV) in-line mixers provide excellent flow rates and the ability to handle higher viscosity products.

The Silverson Ultra Sanitary series of multi-purpose in-line mixers can perform the widest range of applications-mixing, emulsification, homogenization, decomposition and dissolution, with efficiency, flexibility and hygienic structure unmatched by other machines.

The Silverson high-shear in-line mixer has extremely high operating efficiency and rapidity, which can reduce mixing time by up to 90%. The actions of any Silverson in-line mixer can be modified by using fast interchangeable working heads. This enables any machine to mix, emulsify, homogenize, dissolve, suspend, disperse and decompose solids.

Silverson Verso is a benchtop online mixer, which is ideal for laboratory or pilot scale applications. The device provides excellent reproducibility when scaled up and provides an accurate and simple method to predict the performance of large in-line mixers under full-scale operating conditions.

Silverson Ultramix is ​​designed for applications beyond the capabilities of traditional mixers or mixers, but does not necessarily require the intense high shear of Silverson rotor/stator mixers.

The Silverson high-shear batch mixer is not just simple mixing; it emulsifies, homogenizes, dissolves, suspends, disperses and decomposes solids. Each mixer is equipped with a precision-designed Silverson rotor/stator working head, which is far superior to traditional mixers and can shorten processing time by up to 90%, thereby improving quality, product consistency and processing efficiency.

This series of mixers are specially designed for small-scale production in pilot plants, research institutions, hospital pharmacies, etc. The AX series models are light and easy to operate, with a capacity of up to 50 liters.

Like many other hydrocolloids, it can be difficult to disperse CMC using traditional mixers. In this video, learn how the Silverson high-shear mixer provides the fastest and easiest way to disperse and hydrate CMC, ensuring a consistent, non-caking mixture, and helping to shorten processing time and reduce costs.

Silverson L5M-A is very suitable for all laboratory work, R&D, QA analysis and small-scale production in all industries. The L5M-A laboratory mixer is suitable for the widest range of applications—mixing, emulsification, homogenization, disintegration and dissolution—with efficiency and flexibility unmatched by other machines.

Homogenization is the process of making the product completely consistent in terms of particle or pellet size. The Silverson mixer/homogenizer can achieve pellet or droplet sizes in the range of 2 – 5 microns, which is sufficient for most products, including creams, ointments, sauces and drug suspensions.

When making a medicinal cream or ointment into a fine, stable, and well-dispersed active pharmaceutical ingredient (API) emulsion, it is essential to create the right consistency and functionality in the final product. The Silverson mixer can easily produce uniform and stable emulsions with droplet sizes of 2 to 5 microns. Depending on the formulation, a finer emulsion can be obtained.

Silverson's sanitary mixer series is 3A type and EHEDG certified, and its design meets FDA and GMP requirements. Silverson mixers are very suitable for industries where clean-in-place (CIP) and disinfection-in-place (SIP) procedures are regulated.

There are various types of tablet coatings, including traditional sugar-based coatings, film coatings, and enteric coatings. No matter which type of coating you make, this video shows how the Silverson machine can provide you with a uniform mixture to overcome common processing problems, such as spots caused by uneven dispersion of colorants.

Due to increasing inquiries about the mixing equipment used to make hand sanitizer, Silverson has produced a video dedicated to how our equipment can help make hand sanitizer and eliminate common mixing problems that occur when mixing certain key ingredients (such as Carbopol).

Emulsion is a mixture of two or more immiscible liquids-one is oil-based and the other is water-based, or "aqueous." They are described as "immiscible" liquids because they cannot be easily mixed together without separation. This video demonstrates how to add emulsifiers and use a high-shear rotor/stator mixer to evenly disperse ingredients.

When powders are added to liquids, they tend to form agglomerates that are not easily broken down by conventional mixers. The high shear of the Silverson rotor/stator head quickly disperses the agglomerates, exposing more and more solid areas to the surrounding liquid.

Although agitators can handle a wide range of capacities and viscosities, the low-shear characteristics of agitators limit their effectiveness in performing simple tasks, such as mixing liquids of similar viscosity, maintaining uniformity in the tank, and creating flow in the container. Promote the vessel wall from the jacket. The Silverson high-shear rotor/stator mixer is ideal for this type of application, reducing mixing time by up to 90%, thereby increasing yield and product quality, and improving batch-to-batch consistency.

When there is a significant difference in the viscosity between the two liquids, the agitator tends to move the two liquids without actually mixing them together, and it may take a long time to achieve uniform mixing. With the Silverson high-shear mixer, the liquids are mixed almost instantly.

Carboxymethyl cellulose (CMC), also known as cellulose or cellulose gum, is water-soluble and is used to bind free water. Since it has a tendency to form clumps or fish eyes when it comes into contact with the aqueous dispersion of CMC using a conventional agitator, it may cause several problems. Read how high-shear mixers overcome these challenges.

A multinational pharmaceutical company is developing an improved virus to treat and destroy cancerous tumors. To this end, they need equipment that can finely decompose and disperse the materials needed to produce the virus. After successfully trialing the laboratory mixer in the first stage of process development, they cooperated with the manufacturer to purchase the UHS autoclavable design mixer to achieve the same successful results on a larger scale.

A drugmaker contacted Silverson because they wanted to develop a production process for intravenous oncology drugs. The drug will consist of a low-viscosity liquid, in which hormone-based active ingredients (AI) need to be dispersed. The nature of the hormone is a challenge in this application, because it must be dispersed fine enough so that the suspension remains stable and will not separate over time, but it cannot be over-sheared, otherwise the relevant medical effects cannot be guaranteed, and it is effective There is a small margin for mixing and dispersing AI.

A global medical materials manufacturer wants to make a 20% calcium product solid suspension in water with a particle size of 10 microns, which will be done in batches of approximately 55 US gallons. The customer's main goal is to reduce the particle size and speed up their processing time by achieving the required particle size reduction in one pass. Finally, the two-stage online mixer produced the expected results.

A manufacturer is using 5-10 gallon rollers to produce medical pastes using a simple propeller mixer. They cannot quickly produce the required quantity of products, and the small batches of products they can produce take a long time. FMX25 helped them produce larger batches in a shorter time and improved consistent product quality from batch to batch.

A major supplier of gelatin capsules in the pharmaceutical industry that has successfully designed, developed and manufactured a series of innovative solutions is facing the challenge of new processes. When various iron oxides are added as colorants, they will encounter the problem of particles forming clusters, resulting in low yield and uneven coloring. The right mixer helps them reduce particle size and produce high-quality finished products.

The viscosity of highly active surfactants and water are very different. If the surfactant is pumped into the water in the container, it is not easy to mix them with a traditional mixer. This will result in undiluted or partially diluted surfactant pellets. It is best to use a high-shear online mixer for dilution.

Challenges faced by Carbopol include dust problems, formation of clumps that are not easily dispersed, and poor fluidity. The right mixer can avoid these problems.

In order to produce a stable W/O emulsion vaccine that maintains immune-inducing properties, the manufacturing process must achieve small emulsion droplets (<1 µm) with a single peak and narrow particle size distribution. The high shear energy provided by the rotor/stator mixer is required to achieve this goal.

Products produced under sterile or clean room conditions (such as injections and vaccines) face different challenges, especially in terms of product sterilization. For these products, mixing is usually performed before sterilization, but in some cases, post-production sterilization cannot be performed due to technical reasons, which further limits the mixing process.

Contact lens solutions often have a similar basic formula: saline solution (usually 5%), with a series of ingredients added according to the desired function. These include thickeners, surfactants and active ingredients. Preparing a saline solution is a fairly simple task, but stabilizers tend to form clumps that cannot be decomposed by stirring, and require a long mixing time to fully hydrate and dissolve the solids.

The traditional antitussive mixture is formulated around a syrup with a concentration of 60-75%. The syrup is made of sucrose, maltodextrin, glucose, invert syrup, etc. The remaining part consists of thickeners, stabilizers and active ingredients. The use of traditional mixers and agitators in the manufacturing process can cause several potential problems. The high shear mixer allows sugar and active ingredients to dissolve at ambient temperature to avoid problems.

Cream or ointment products can be water-in-oil (w/o) or oil-in-water (o/w) emulsions, consisting of waxes, emollients and lubricants dispersed in the oil phase and containing emulsifying, stabilizing and thickening agents The water phase composition agent, preservative, and in some cases, coloring agent. The active ingredient is dispersed in either phase or added after the emulsion is formed and cooled. Read how to reduce mixing time while improving product uniformity and consistency.

The testing of products such as drug suspensions and tablet coatings is a key part of the quality assurance process. In some cases, each batch of each product must be tested, which requires 100% repeatability of the results. Sample preparation may involve disintegration of solids (eg tablets), dispersing powders into liquids, intimate mixing of liquid/liquid or liquid/solid components to accelerate the reaction, etc. The right mixer can perform these tasks efficiently and achieve repeatable results.

Obtaining an agglomerate-free dispersion is essential to ensure a clear and bright gel after neutralization, but it is difficult to incorporate low-density powders (such as Carbopol) into the liquid using traditional mixers. The high-shear mixing of the Silverson mixer ensures rapid incorporation and dispersion of powders to form a clump-free solution while minimizing aeration.

There are various types of tablet coatings, including traditional sugar-based coatings, film coatings, and enteric coatings. No matter what type of paint you produce, the Silverson high-shear mixer can provide you with uniform and consistent mixing and overcome common processing problems such as spots caused by uneven dispersion of colorants.